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Antiproliferative ruthenium complexes

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Antiproliferative ruthenium complexes

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Project Description:

This interdisciplinary project will incorporate the disciplines of chemistry and biology. However the project is specifically housed within the Hope College Department of Chemistry. The platinum-based drug cisplatin is a highly toxic, highly effective anticancer therapeutic. This compound poisons both normal and cancer cells indiscriminately, and this toxicity causes the devastating side effects of chemotherapy. The convergent project described here involves the synthesis of new ruthenium-based drugs (chemistry) and testing of these drugs in cancer cells (biology) for antiproliferative and antimetastatic activity. One goal of the project is to improve the specificity of the drugs towards cancer cells in order to reduce toxicity towards normal cells. To accomplish this, we will incorporate targeting groups in the molecular structure of the drug and test the toxicity in normal cells as well as cancer cells. A second goal is to investigate the biochemical pathways by which these new drugs induce cell death.

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