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Targeting b-amyloid aggregation with transition metals

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Targeting b-amyloid aggregation with transition metals

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Project Description:

Alzheimer’s Disease (AD) is a neurodegenerative disease that affects more than 5 million Americans, and is currently the 6th leading cause of death in the United States. Aggregration of misfolded Abeta(1-42) protein is implicated in memory loss and degeneration of the brain in AD patients. Previous researchers have focused on using a transition metal to target the histidine residues in Abeta(1-42) to prevent metal binding and lower toxicity. Other work has shown that the peptide KLVFFA inhibits the oligomerization of Abeta(1-42). Our research aims to develop a more potent approach by combining the inhibitory activity of KLVFFA with the histidine-binding activity of ruthenium complexes in order to disrupt the oligomerization of Abeta(1-42). Students will learn peptide synthesis, inorganic chemistry, and do biophysical studies. This project is specifically housed within the Hope College Department of Chemistry.

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