Project Description: |
The goal of systems biology is to build computer models that use genetic information about an organism to simulate and predict its behavior. These models are useful for determining how organisms respond to perturbations in their environment, e.g., how bacteria respond to antibiotics. Over the past three summers, students involved in this project have developed software to automatically generate metabolic models for the microbial organisms represented in the SEED, a comparative genomics analysis environment (www.theseed.org). This summer, we will develop additional tools for manually refining these models so that they are suitable for systems level analysis. We will work with Perl, CGI, Ajax, and Java. Knowledge of molecular biology, microbiology and genetics is helpful but not necessary. |
